5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid

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Chemical Name:5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid
CAS No.:710322-36-4
Molecular Formula:C₂₀H₂₂ClN₃O₅S
Molecular Weight:451.931
Hs Code.:

Synonyms:5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid

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Chemical Property of 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid

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Technology Process of 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid

There total 3 articles about 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 169335-50-6
5-chloropyrazine-2-carboxylic acid tert-butyl ester

: 710322-36-4
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: silver fluoride / acetonitrile / Inert atmosphere

1.2: Inert atmosphere

2.1: Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1.08 h / 20 °C / Inert atmosphere

With silver fluoride; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/ml400027y

Reference yield:

: 36070-80-1
5-chloropyrazinoic acid

: 710322-36-4
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; cyclohexane / 0.08 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: silver fluoride / acetonitrile / Inert atmosphere

2.2: Inert atmosphere

3.1: Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1.08 h / 20 °C / Inert atmosphere

With silver fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; cyclohexane; acetonitrile;
DOI:10.1021/ml400027y

Reference yield:

: 710322-34-2
5-amino-pyrazine-2-carboxylic acid tert-butyl ester

: 710322-36-4
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1.08 h / 20 °C / Inert atmosphere

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ml400027y