5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide

Base Information

Chemical Name:5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide
CAS No.:710321-51-0
Molecular Formula:C₂₀H₂₃ClN₄O₅S
Molecular Weight:466.945
Hs Code.:

Synonyms:5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide

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Chemical Property of 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide

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Technology Process of 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide

There total 6 articles about 5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 710322-37-5
5-[2(R)-(3-chloro-4-methanesulfonylphenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tert-butoxy-amide

: 710321-51-0
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 - 40 ℃;

Reference yield:

: 710322-35-3
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid tertbutyl ester

: 710321-51-0
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1.08 h / 20 °C / Inert atmosphere

2.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2.75 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 - 40 °C / Inert atmosphere

With oxalyl dichloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml400027y

Reference yield:

: 169335-50-6
5-chloropyrazine-2-carboxylic acid tert-butyl ester

: 710321-51-0
5-[2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-pyrazine-2-carboxylic acid hydroxyamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver fluoride / acetonitrile / Inert atmosphere

1.2: Inert atmosphere

2.1: Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1.08 h / 20 °C / Inert atmosphere

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

4.2: 2.75 h / 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 20 - 40 °C / Inert atmosphere

With oxalyl dichloride; silver fluoride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml400027y