6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine

Base Information

• Chemical Name: 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine
• CAS No.: 1621432-05-0
• Molecular Formula: C₂₄H₁₉N₃OS
• Molecular Weight: 397.5
• Mol file: 1621432-05-0.mol

Synonyms:6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine

Chemical Property of 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine

There total 5 articles about 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(benzo[d]imidazo[2,1-b]thiazol-2-yl)aniline (1621432-63-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine (1621432-05-0)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; tetrabutylammomium bromide; In water; at 80 ℃; for 3.25h;

DOI:10.1039/c4ra03415e

Reference yield:

1-(2,2-dibromovinyl)-2-nitrobenzene (253684-24-1) → 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine (1621432-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 6 h / Heating

2: acetic acid; iron / 0.67 h / 90 °C

3: 1,3,5-trichloro-2,4,6-triazine; tetrabutylammomium bromide / water / 3.25 h / 80 °C

With 1,3,5-trichloro-2,4,6-triazine; tetrabutylammomium bromide; iron; sodium hydrogencarbonate; acetic acid; In water; N,N-dimethyl-formamide; 1: |Pictet-Spengler Synthesis / 3: |Pictet-Spengler Synthesis;

DOI:10.1039/c4ra03415e

Reference yield:

2-nitro-benzaldehyde (552-89-6) → 6-methyl-6-(4-methoxyphenyl)-5,6-dihydro-(11-S)-5,6b,12-triaza-benzo[a]fluorine (1621432-05-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4.25 h / 0 - 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 6 h / Heating

3: acetic acid; iron / 0.67 h / 90 °C

4: 1,3,5-trichloro-2,4,6-triazine; tetrabutylammomium bromide / water / 3.25 h / 80 °C

With 1,3,5-trichloro-2,4,6-triazine; carbon tetrabromide; tetrabutylammomium bromide; iron; sodium hydrogencarbonate; acetic acid; triphenylphosphine; In dichloromethane; water; N,N-dimethyl-formamide; 2: |Pictet-Spengler Synthesis / 4: |Pictet-Spengler Synthesis;

DOI:10.1039/c4ra03415e

upstream raw materials:

1-(2,2-dibromovinyl)-2-nitrobenzene

2-nitro-benzaldehyde

2-(benzo[d]imidazo[2,1-b]thiazol-2-yl)aniline

1-(4-methoxyphenyl)ethanone

Refernces