(1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide

Base Information

• Chemical Name: (1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide
• CAS No.: 1450628-72-4
• Molecular Formula: C₂₅H₃₂N₄O₁₀
• Molecular Weight: 548.55
• Mol file: 1450628-72-4.mol

Synonyms:(1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide

Chemical Property of (1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide

There total 1 articles about (1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0) + diethylmalonyl chloride (54505-72-5) → (1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide (1450628-72-4)

Guidance literature:

With sodium acetate; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1007/s11172-012-0307-z

Reference yield: 76.0%

(1S,1'S,2S,2'S)-N,N'-bis[1,3-dihydroxy-1-(4-nitrophenyl)prop-2-yl]diethylmalonamide (1450628-72-4) → 2,2'-(pentane-3,3-diyl)bis{4(S)-[1(S)-hydroxy-1(S)-(4-nitrophenyl)methyl]-4,5-dihydrooxazole} (1450628-66-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -5 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1007/s11172-012-0307-z

upstream raw materials:

(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol

diethylmalonyl chloride

Downstream raw materials:

2,2'-(pentane-3,3-diyl)bis{4(S)-[1(S)-hydroxy-1(S)-(4-nitrophenyl)methyl]-4,5-dihydrooxazole}