54505-72-5

Usage

Uses

Used in Pharmaceutical Industry:
DIETHYLMALONIC ACID DICHLORIDE is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its ability to react with different reagents allows for the creation of a diverse range of therapeutic agents.
Used in Chemical Synthesis:
DIETHYLMALONIC ACID DICHLORIDE is used as a key building block in the synthesis of complex organic molecules. Its reactivity and compatibility with various reaction conditions make it a valuable component in the development of new chemical products.
Specific Applications:
1. Preparation of 5,5-diethyl-1,3-dihydroxybarbituric acid (N,N′-dihydroxyveronal): DIETHYLMALONIC ACID DICHLORIDE is used as a reactant in the condensation process with 1,3-dibenzyloxyurea, leading to the formation of this specific barbiturate compound.
2. Synthesis of 1,11-dibronzo-4,8-diaza-6,6-diethyl-5,7-dioxoundecaneamide containing crowned derivatives of dithiomaleonitrile: DIETHYLMALONIC ACID DICHLORIDE plays a crucial role in the synthesis of this complex molecule, showcasing its versatility in creating a wide range of chemical products.

InChI:InChI=1/C7H10Cl2O2/c1-3-7(4-2,5(8)10)6(9)11/h3-4H2,1-2H3

Upstream product

• 510-20-3 diethyl malonic acid 
• 2736-40-5 chlorure d'acide ethyl-2 butyrique 
• 503-38-8 trichloromethyl chloroformate 
• 57-44-3 diethylbarbituric acid 
• 77-25-8 diethyl diethylmalonate 

Downstream Products

• 92108-24-2 3,3-Diethyl-1-(phenylamino)-2,4-azetidindion 
• 1732-61-2 1-phenyl-4,4-diethyl-3,5-pyrazolidinedione 
• 29264-10-6 diethyl-malonic acid bis-(N'-phenyl-hydrazide) 
• 102165-22-0 4,4-diethyl-1-(1-methyl-piperidin-4-yl)-2-phenyl-pyrazolidine-3,5-dione 
• 98542-55-3 3,3-diethyl-1-[benzoyl-(1-methyl-[4]piperidyl)-amino]-azetidine-2,4-dione 
• 97257-90-4 1-benzoyl-4,4-diethyl-2-(1-methyl-piperidin-4-yl)-pyrazolidine-3,5-dione 
• 114792-58-4 3,3-diethyl-1-[(2-benzyloxy-benzoyl)-(1-methyl-[4]piperidyl)-amino]-azetidine-2,4-dione 
• 64289-52-7 acide diethyl-5,5 imino-2 barbiturique 
• 64289-52-7 2-amino-5,5-diethyl-1H-pyrimidine-4,6-dione 
• 101496-40-6 3,3-diethyl-1-(4-dimethylamino-phenyl)-azetidine-2,4-dione 
• 66940-97-4 5,5-diethyl-2-anilino-1H-pyrimidine-4,6-dione 
• 96973-14-7 3,3-diethyl-1-(N-benzyl-anilino)-azetidine-2,4-dione 
• 100958-18-7 1-(N-acetyl-anilino)-3,3-diethyl-azetidine-2,4-dione 
• 77-32-7 thiobarbital 

Relevant academic research and scientific papers

Copper(II)-catalyzed enantioselective intramolecular cyclization of N-alkenylureas

The first Cu(II)-catalyzed highly enantioselective intramolecular cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.

Synthesis, characterization and antimicrobial activity of novel pharmacophores incorporating imidazoline-oxazoline scaffold

In this work, synthesis, characterization and antimicrobial activity of series of imidazolines-oxazolines scaffolds 5a-f and 10a-d have been investigated. All the imidazolines-oxazolines derivatives were prepared from acid derivatives 1 and 6a-c, and enan

Highly enantioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones with simple Cu(II)-oxazoline-imidazoline catalysts

A series of novel chiral ligands L1-L4 with an imidazoline-oxazoline framework have been developed as new type of non-symmetric N,N-bidentate ligands. All the chiral ligands were prepared from 2,2-diethylmalonic acid and enantiomerically pure (S)-2-amino-

Photochemical transformation of trithiobarbiturate into thiohydantoin and imidazolinothiophene derivatives

Upon irradiation of trithiobarbiturate (1), ring contraction reaction occurred to give thiohydantoin (2 or 3) and imidazolinothiophene (4) derivatives. Further, on treating with iodine, the thiohydantoins (2 and 3) undergo ring closure, giving imidazolino