(S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine

Base Information

• Chemical Name: (S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine
• CAS No.: 195455-99-3
• Molecular Formula: C₂₉H₃₅F₂N₃O
• Molecular Weight: 479.613

Synonyms:(S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine

Chemical Property of (S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine

There total 2 articles about (S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-[4,4-bis(4-fluorophenyl)butyl]piperazine (5631-35-6) + (S)-(+)-1-chloro-3-(phenylamino)-propan-2-ol (195455-97-1) → (S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine (195455-99-3)

Guidance literature:

With potassium carbonate; potassium iodide; In ethanol; for 4h; Heating;

DOI:10.1016/j.bmc.2004.02.041

Reference yield:

aniline (62-53-3) → (S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine (195455-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / ethanol / 2.5 h / Heating

2: 90 percent / potassium carbonate; potassium iodide / ethanol / 4 h / Heating

With potassium carbonate; potassium iodide; In ethanol;

DOI:10.1016/j.bmc.2004.02.041

Reference yield: 94.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (S)-(+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-hydroxy-3-(phenylamino)propyl]piperazine (195455-99-3) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-{4-[4,4-bis-(4-fluoro-phenyl)-butyl]-piperazin-1-yl}-1-phenylaminomethyl-ethyl ester

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2004.02.041

upstream raw materials:

1-[4,4-bis(4-fluorophenyl)butyl]piperazine

(S)-(+)-1-chloro-3-(phenylamino)-propan-2-ol

aniline

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