(R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate

Base Information

• Chemical Name: (R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate
• CAS No.: 117068-41-4
• Molecular Formula: C₃₀H₃₀N₂O₆
• Molecular Weight: 514.578
• Mol file: 117068-41-4.mol

Synonyms:(R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate

Chemical Property of (R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate

There total 2 articles about (R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

thymin (65-71-4,28806-14-6,691841-57-3) + methyl (E)-3-<2-(trityloxy)ethoxy>propenoate (117068-40-3) → (R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate (117068-41-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; acetonitrile; for 504h; Ambient temperature;

DOI:10.1021/jm00121a015

Reference yield:

trityl 2-hydroxyethyl ether (18325-45-6) → (R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate (117068-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N / diethyl ether / 67 h / Ambient temperature

2: 83 percent / DBU / acetonitrile; dimethylsulfoxide / 504 h / Ambient temperature

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In diethyl ether; dimethyl sulfoxide; acetonitrile;

DOI:10.1021/jm00121a015

Reference yield: 81.0%

(R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate (117068-41-4) → (R,S)-1-<1-<2-(trityloxy)ethoxy>-3-hydroxypropyl>thymine (117068-42-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm00121a015

upstream raw materials:

thymin

methyl (E)-3-<2-(trityloxy)ethoxy>propenoate

trityl 2-hydroxyethyl ether

Downstream raw materials:

(R,S)-1-<1-<2-(trityloxy)ethoxy>-3-hydroxypropyl>thymine

(R,S)-1-[1-(2-hydroxyethoxy)-3-hydroxypropyl]thymine

(R,S)-1-[1-(2-hydroxyethoxy)-3-azidopropyl]thymine

(R,S)-1-<1-<2-(trityloxy)ethoxy>-3-azidopropyl>thymine