18325-45-6

Usage

Uses

Used in Organic Synthesis:
2-(trityloxy)ethanol is used as a solvent and chemical intermediate for its ability to facilitate various chemical reactions due to the stability and protection provided by the trityl group to the hydroxyl group.
Used in Pharmaceutical Production:
It is utilized as a key component in the synthesis of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Polymer Production:
2-(trityloxy)ethanol is used as a chemical intermediate in the production of polymers, enhancing their properties and performance.
Used in Specialty Chemicals:
2-(trityloxy)ethanol is employed in the creation of specialty chemicals, where its unique properties are leveraged for specific applications.
Used in Coatings, Adhesives, and Sealants:
2-(trityloxy)ethanol is used as an antioxidant in the formulation of coatings, adhesives, and sealants to improve their durability and resistance to degradation.

Upstream product

• 76-83-5 trityl chloride 
• 107-21-1 ethylene glycol 
• 68883-09-0 1,2-bis-trityloxy-ethane 
• 119248-80-5 ((2R,3R,4S)-1,3,4,5-tetrahydroxy-6-(trityloxy)hexan-2-yl)acetamide 
• 596-43-0 bromo-triphenyl-methane 
• 110-86-1 pyridine 
• 76-84-6 triphenylmethyl alcohol 
• 112289-48-2 2-Acetamido-2-deoxy-6-O-trityl-D-glucose 

Downstream Products

• 68883-09-0 1,2-bis-trityloxy-ethane 
• 107-21-1 ethylene glycol 
• 117068-40-3 methyl (E)-3-<2-(trityloxy)ethoxy>propenoate 
• 110596-03-7 2-(trityloxy)ethyl 4-methylbenzenesulfonate 
• 207982-96-5 1-chloro-1,1,3,3-tetraisopropyl-3-[2-(triphenylmethoxy)ethoxy]disiloxane 
• 131029-42-0 (2-(triphenylmethoxy)ethoxy)acetic acid 
• 618106-86-8 2-(trityloxy)ethyl 4,6-di-O-acetyl-2,3-di-O-benzoyl-α-D-mannopyranoside 
• 330183-81-8 2-fluoro-3,5-dinitro-benzoic acid 2-trityloxy-ethyl ester 
• 131029-43-1 ethyl 2-(trityloxy)ethoxyacetate 
• 117068-42-5 (R,S)-1-<1-<2-(trityloxy)ethoxy>-3-hydroxypropyl>thymine 
• 117068-41-4 (R,S)-methyl 3-thymin-1-yl-3-<2-(trityloxy)ethoxy>propanoate 
• 117068-44-7 (R,S)-1-<1-<2-(trityloxy)ethoxy>-3-azidopropyl>thymine 
• 117068-43-6 Methanesulfonic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-trityloxy-ethoxy)-propyl ester 
• 102478-39-7 1-bromo-2-(triphenylmethoxy)ethane 

Relevant academic research and scientific papers

Mesomorphism and glass formation of phthalocyanine metal complexes with bulky substituents

This paper deals with the synthesis of phthalocyanine complexes, containing four oligo(oxyethylene)-, oxybenzene-, esther of p-oxybenzoic acid or p-oxyazobenzene side chains terminated by a bulky trityl substituent. Their purity was established by column

FLUORINE-CONTAINING ETHER COMPOUND, LUBRICANT FOR MAGNETIC RECORDING MEDIUM, AND MAGNETIC RECORDING MEDIUM

The present invention relates to a fluorine-containing ether compound represented by Formula (1), [in-line-formulae]R1—R2—CH2—R3—CH2—R4??(1).[/in-line-formulae] (In Formula (1), R1 /s

Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics

The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomimetics. As most amino acids have a chiral center at Cα, such amide bond surrogates need a chiral moiety. Here the asymmetric synthesis of a set of 24 N-sulfinyl propargylamines is presented. The condensation of various aldehydes with Ellman's chiral sulfinamide provides chiral N-sulfinylimines, which were reacted with (trimethylsilyl)ethynyllithium to afford diastereomerically pure N-sulfinyl propargylamines. Diverse functional groups present in the propargylic position resemble the side chain present at the Cα of amino acids. Whereas propargylamines with (cyclo)alkyl substituents can be prepared in a direct manner, residues with polar functional groups require suitable protective groups. The presence of particular functional groups in the side chain in some cases leads to remarkable side reactions of the alkyne moiety. Thus, electron-withdrawing substituents in the Cα-position facilitate a base induced rearrangement to α,β-unsaturated imines, while azide-substituted propargylamines form triazoles under surprisingly mild conditions. A panel of propargylamines bearing fluoro or chloro substituents, polar functional groups, or basic and acidic functional groups is accessible for the use as precursors of peptidomimetics.

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.

MELANIN PRODUCTION INHIBITOR

Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent. At least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group. When one of R1 and R2 is an oxo group, the other is not present. R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

Influence of the spacer length on the phase behaviors of mesogen-jacketed liquid crystalline polymers with a bulk side-chain

A series of mesogen-jacketed liquid-crystalline polymers (MJLCPs) containing two triphenylmethyl (Tr) units in the side chains, named poly{2,5-bis[(triphenylmethoxy-alkyl)oxycarbonyl]-styrenes} (denoted as Pv-m-Tr, m = 2, 4, 6, 8, 10, 12, which is the num

METHOD FOR PREPARING EVEROLIMUS AND ITS INTERMEDIATES

The present invention relates to a manufacturing method of everolimus and an intermediate thereof, and more specifically, to a manufacturing method comprising: a first step of manufacturing a compound of chemical formula 2 by reacting rapamycin of chemical formula 3 and 2-(trityl oxy)ethyl methane sulfonate; and a second step of manufacturing the everolimus of chemical formula 1 by deprotecting the manufactured compound of the chemical formula 2. The present invention is able to manufacture the everolimus with a high yield using a easier and simpler method compared to conventional methods. In the chemical formula 2, R1 is triphenyl methane.COPYRIGHT KIPO 2015

N-Substituted Benzenepropanamide and Benzenepropenamide For Use in the Prevention or the Treatment of Affective Disorders

Compounds for use in the treatment or prophylaxis of an affective disorder, which compound is represented by formula I in which the dotted line represents a single or a double bond; and R5 and R5′ are independently —H, —OH or —OR6, where R6 is a linear or branched C1-C4 alkyl; X is —CH2O—; Z is —CH2OH2O—, —CH(CH3)CH2O— or —CH2CH(CH3)O—; m is 1; and n is an integer of 1-5; or a pharmaceutically acceptable salt, prodrug, metabolite, or hydrate thereof.