1H-Indazole-4-carboxaMide,6-broMo-1-cyclopentyl-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-

Base Information

Chemical Name:1H-Indazole-4-carboxaMide,6-broMo-1-cyclopentyl-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-
CAS No.:1346703-22-7
Molecular Formula:C₂₁H₂₃BrN₄O₂
Molecular Weight:443.343
Hs Code.:
Mol file:1346703-22-7.mol

Synonyms:6-bromo-1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

Suppliers and Price of 1H-Indazole-4-carboxaMide,6-broMo-1-cyclopentyl-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 1H-Indazole-4-carboxaMide,6-broMo-1-cyclopentyl-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1H-Indazole-4-carboxaMide,6-broMo-1-cyclopentyl-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-

There total 6 articles about 1H-Indazole-4-carboxaMide,6-broMo-1-cyclopentyl-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1173081-96-3
(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methylamine hydrochloride

: 1346703-24-9
6-bromo-1-cyclopentyl-1H-indazole-4-carboxylic acid

: 1346703-22-7
6-bromo-1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 769-28-8
3-Cyano-4,6-dimethyl-2(1H)-pyridon

: 1346703-22-7
6-bromo-1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; sodium acetate; acetic acid / palladium 10% on activated carbon; platinum(IV) oxide / 48 h / 5171.62 Torr

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dimethyl sulfoxide / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium acetate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; palladium 10% on activated carbon; In dimethyl sulfoxide;

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethylpyridin-2-ol

: 1346703-24-9
6-bromo-1-cyclopentyl-1H-indazole-4-carboxylic acid

: 1346703-22-7
6-bromo-1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01501