(2S,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine

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Chemical Name:(2S,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine
CAS No.:1382680-58-1
Molecular Formula:C₄₇H₄₇NO₅
Molecular Weight:705.894
Hs Code.:

Synonyms:(2S,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine

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Chemical Property of (2S,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine

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Technology Process of (2S,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine

There total 1 articles about (2S,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 944543-93-5
(3S,4R,5R)-5-benzyloxymethyl-3,4-dibenzyloxy-1-(4-methoxybenzyl)-pyrrolidin-2-one

: 120186-59-6
(4-(benzyloxy)phenyl)magnesium bromide

: 1382680-48-9
(2R,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine

: 1382680-58-1
(2S,3R,4R,5R)-1-(4-methoxybenzyl)-3,4-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-(benzyloxymethyl)pyrrolidine

Guidance literature:: (3S,4R,5R)-5-benzyloxymethyl-3,4-dibenzyloxy-1-(4-methoxybenzyl)-pyrrolidin-2-one; With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 ℃; for 0.75h;

(4-(benzyloxy)phenyl)magnesium bromide; In tetrahydrofuran; dichloromethane; at -78 - 20 ℃; for 1h;

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In tetrahydrofuran; dichloromethane; at -78 - 20 ℃; for 1h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2012.01.085