4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane

Base Information

• Chemical Name: 4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane
• CAS No.: 89276-34-6
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.322
• Mol file: 89276-34-6.mol

Synonyms:4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane

Chemical Property of 4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane

There total 3 articles about 4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-Phenyl-butyric acid 3-methyl-oxetan-3-ylmethyl ester (89276-30-2) → 4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane (89276-34-6)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -15 ℃; for 12h;

DOI:10.1016/S0040-4039(00)94143-1

Reference yield:

3-hydroxymethyl-3-methyloxethane (3143-02-0) → 4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane (89276-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / pyridine / CH₂Cl₂ / 0 °C

2: 75 percent / BF₃*Et₂O / CH₂Cl₂ / 12 h / -15 °C

With pyridine; boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1016/S0040-4039(00)94143-1

Reference yield:

2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) → 4-Methyl-1-(3-phenyl-propyl)-2,6,7-trioxa-bicyclo[2.2.2]octane (89276-34-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 20percent KOH in ethanol / various solvent(s) / 0.25 h / Heating

2: 75 percent / pyridine / CH₂Cl₂ / 0 °C

3: 75 percent / BF₃*Et₂O / CH₂Cl₂ / 12 h / -15 °C

With pyridine; potassium hydroxide; boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1016/S0040-4039(00)94143-1

upstream raw materials:

4-Phenyl-butyric acid 3-methyl-oxetan-3-ylmethyl ester

3-hydroxymethyl-3-methyloxethane

2-(hydroxymethyl)-2-methylpropane-1,3-diol