(R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Base Information

Chemical Name:(R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester
CAS No.:1402225-46-0
Molecular Formula:C₂₈H₃₇NO₈
Molecular Weight:515.604
Hs Code.:

(R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Synonyms:(R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Suppliers and Price of (R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

There total 9 articles about (R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402225-45-9
(R)-2-tert-butoxycarbonylamino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

: 1402225-46-0
(R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 2h; Reflux;

Reference yield:

: 1261570-98-2
2-bromo-5-iodobenzoyl chloride

: 1402225-46-0
(R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2.1: trifluoroacetic acid; trifluorormethanesulfonic acid; triethylsilane / 0.42 h / 20 °C

3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 1 h / -78 °C

3.3: 16 h / 20 °C

4.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 4 h / 10 °C

5.1: dmap; pyridine / dichloromethane / 2 h / 20 °C

6.1: tricyclohexylphosphine; potassium phosphate / toluene; water / 0.75 h

6.2: Reflux

7.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol

8.1: dmap; pyridine / 16 h / 20 - 80 °C

9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 0 - 20 °C

9.2: 0 - 20 °C

10.1: aluminum (III) chloride / dichloromethane; diethyl ether / 2 h / 0 - 20 °C

11.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

11.2: 0 - 20 °C

12.1: palladium(II) hydroxide / ethyl acetate; methanol / 20 °C

13.1: hydrogenchloride / methanol / 2 h / 20 °C / Reflux

With pyridine; hydrogenchloride; triethylsilane; dmap; aluminum (III) chloride; potassium phosphate; n-butyllithium; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; palladium(II) hydroxide; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; tricyclohexylphosphine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 25252-00-0
2-bromo-5-iodobenzoic acid

: 1402225-46-0
(R)-2-amino-3-methyl-butyric acid (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

3.1: trifluoroacetic acid; trifluorormethanesulfonic acid; triethylsilane / 0.42 h / 20 °C

4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 1 h / -78 °C

4.2: 1 h / -78 °C

4.3: 16 h / 20 °C

5.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 4 h / 10 °C

6.1: dmap; pyridine / dichloromethane / 2 h / 20 °C

7.1: tricyclohexylphosphine; potassium phosphate / toluene; water / 0.75 h

7.2: Reflux

8.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol

9.1: dmap; pyridine / 16 h / 20 - 80 °C

10.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 0 - 20 °C

10.2: 0 - 20 °C

11.1: aluminum (III) chloride / dichloromethane; diethyl ether / 2 h / 0 - 20 °C

12.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.5 h / 20 °C

12.2: 0 - 20 °C

13.1: palladium(II) hydroxide / ethyl acetate; methanol / 20 °C

14.1: hydrogenchloride / methanol / 2 h / 20 °C / Reflux

With pyridine; hydrogenchloride; triethylsilane; dmap; aluminum (III) chloride; potassium phosphate; n-butyllithium; oxalyl dichloride; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; palladium(II) hydroxide; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; tricyclohexylphosphine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;