(+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone

Base Information

• Chemical Name: (+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone
• CAS No.: 173547-32-5
• Molecular Formula: C₉H₁₅NO₃
• Molecular Weight: 185.223
• Mol file: 173547-32-5.mol

Synonyms:(+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone

Chemical Property of (+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone

There total 1 articles about (+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Nitroethane (79-24-3) + 3-methylcyclohexen-2-one (1193-18-6) → (+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone (173547-32-5)

Guidance literature:

With C₂₆H₃₅N₅S; In ethyl acetate; at 20 ℃; for 120h;

DOI:10.1039/b804540b

Reference yield:

(+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone (173547-32-5) → 3-Acetyl-3-methylcyclohexanone (173547-35-8)

Guidance literature:

With potassium hydroxide; potassium permanganate; magnesium sulfate; In methanol; 1.) r.t., 2. ) reflux;

DOI:10.1071/CH9951827

Reference yield:

(+/-)-3-methyl-3-(1'-nitroethyl)cyclohexanone (173547-32-5) → methyl 1-methylcyclohexyl ketone (2890-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KMnO₄, KOH, MgSO₄ / methanol / 1.) r.t., 2. ) reflux

2: 30 percent Chromat_. / Zn, aq. HCl / 1.5 h / Heating

With hydrogenchloride; potassium hydroxide; potassium permanganate; magnesium sulfate; mercury; zinc; In methanol;

DOI:10.1071/CH9951827

upstream raw materials:

Nitroethane

3-methylcyclohexen-2-one

Downstream raw materials:

3-Acetyl-3-methylcyclohexanone

methyl 1-methylcyclohexyl ketone

Refernces

• 1、 Malmgren, Marcus,Granander, Johan,Amedjkouh, Mohamed. "Asymmetric conjugate addition of nitroalkanes to enones with a chiral α-aminophosphonate catalyst". . p. 1934 - 1940. Retrieved 2008/12/22.