5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one

Base Information

• Chemical Name: 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one
• CAS No.: 1588429-77-9
• Molecular Formula: C₁₇H₁₆INO₃S
• Molecular Weight: 441.289
• Mol file: 1588429-77-9.mol

Synonyms:5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one

Chemical Property of 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one

There total 5 articles about 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(4-iodophenyl)-N-methylmethacrylamide (1287759-64-1) + Benzenesulfinic acid (618-41-7) → 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one (1588429-77-9)

Guidance literature:

With Iron(III) nitrate nonahydrate; In acetonitrile; at 100 ℃; for 12h; regioselective reaction; Schlenk technique;

DOI:10.1039/c4cc00401a

Reference yield: 82.0%

N-(4-iodophenyl)-N-methylmethacrylamide (1287759-64-1) + diphenyldisulfane (882-33-7) → 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one (1588429-77-9)

Guidance literature:

With dipotassium peroxodisulfate; In water; acetonitrile; at 80 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201600200

Reference yield: 58.0%

N-(4-iodophenyl)-N-methylmethacrylamide (1287759-64-1) + benzenesufonyl hydrazide (80-17-1) → 5-iodo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one (1588429-77-9)

Guidance literature:

With dipotassium peroxodisulfate; tetra-(n-butyl)ammonium iodide; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.joc.6b00773

upstream raw materials:

N-(4-iodophenyl)methacrylamide

N-(4-iodophenyl)-N-methylmethacrylamide

Benzenesulfinic acid

p-aminoiodobenzene