8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

Base Information

Chemical Name:8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane
CAS No.:159638-82-1
Molecular Formula:C₁₉H₂₅NO₅
Molecular Weight:347.411
Hs Code.:

Synonyms:8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

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Chemical Property of 8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

Chemical Property:

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Technology Process of 8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

There total 6 articles about 8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 159638-81-0
Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

: 159638-82-1
8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

Guidance literature:: With potassium carbonate; In methanol;
DOI:10.1016/S0040-4039(98)00797-7

Reference yield:

: 66500-55-8
cyclohexanone-4-carboxylic acid ethyleneacetal

: 159638-82-1
8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; BuLi / tetrahydrofuran; hexane / 1 h / 20 °C

1.2: 78 percent / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: diphenylphosphoryl azide; triethylamine / benzene / 0.5 h / Heating

2.2: 65 percent / benzene / 5 h / Heating

3.1: 94 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

4.1: 86 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 4 h / 20 °C

5.1: 91 percent / K₂CO₃ / methanol / 1 h / 20 °C

With dmap; osmium(VIII) oxide; n-butyllithium; diphenylphosphoranyl azide; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; In tetrahydrofuran; pyridine; methanol; hexane; water; acetone; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(02)00436-2

Reference yield:

: 159638-73-0
8-(2'-propenyl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid

: 159638-82-1
8-(2',3'-epoxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenylphosphoryl azide; triethylamine / benzene / 0.5 h / Heating

1.2: 65 percent / benzene / 5 h / Heating

2.1: 94 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

3.1: 86 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 4 h / 20 °C

4.1: 91 percent / K₂CO₃ / methanol / 1 h / 20 °C

With dmap; osmium(VIII) oxide; diphenylphosphoranyl azide; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; In pyridine; methanol; water; acetone; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(02)00436-2