Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester
CAS No.:159638-81-0
Molecular Formula:C₂₆H₃₃NO₈S
Molecular Weight:519.616
Hs Code.:

Synonyms:Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

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Chemical Property of Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

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Technology Process of Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

There total 6 articles about Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 98-59-9
p-toluenesulfonyl chloride

: 159638-80-9
8-(2',3'-dihydroxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane

: 159638-81-0
Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

Guidance literature:: With dmap; In pyridine; at 20 ℃; for 4h;
DOI:10.1016/S0040-4020(02)00436-2

Reference yield: 86.0%

: 98-59-9
p-toluenesulfonyl chloride

: 159638-79-6
8-phenylmethoxycarbonylamino-8-(2'-propenyl)-1,4-dioxaspiro[4.5]decane

: 159638-81-0
Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

Guidance literature:: With dmap; In pyridine;
DOI:10.1016/S0040-4039(98)00797-7

Reference yield:

: 66500-55-8
cyclohexanone-4-carboxylic acid ethyleneacetal

: 159638-81-0
Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; BuLi / tetrahydrofuran; hexane / 1 h / 20 °C

1.2: 78 percent / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: diphenylphosphoryl azide; triethylamine / benzene / 0.5 h / Heating

2.2: 65 percent / benzene / 5 h / Heating

3.1: 94 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

4.1: 86 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 4 h / 20 °C

With dmap; osmium(VIII) oxide; n-butyllithium; diphenylphosphoranyl azide; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; In tetrahydrofuran; pyridine; hexane; water; acetone; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(02)00436-2