2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine

Base Information

Chemical Name:2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine
CAS No.:1394387-90-6
Molecular Formula:C₂₀H₂₅Cl₂N₃O
Molecular Weight:394.344
Hs Code.:

Synonyms:2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine

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Chemical Property of 2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine

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Technology Process of 2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine

There total 9 articles about 2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: C₂₀H₂₃Cl₂N₃O

: 1394387-90-6
2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine

Guidance literature:: With sodium tris(acetoxy)borohydride; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.12.056

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1394387-90-6
2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 3 h / 0 °C

2.1: potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; 1,4-dioxane / 17 h / 80 °C

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 85 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

5.1: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C

6.1: hydrazine hydrate / ethanol / 2 h / 70 °C

7.1: dichloromethane / 2 h / Molecular sieve

8.1: sodium tris(acetoxy)borohydride / 2 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium acetate; sodium tris(acetoxy)borohydride; sodium carbonate; hydrazine hydrate; diisopropylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; 6.1: |Gabriel Amine Synthesis;
DOI:10.1016/j.ejmech.2013.12.056

Reference yield:

: 18282-59-2
4-bromo-1,2-dichlorobenzene

: 1394387-90-6
2-(4-(3,4-dichlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5yl)methyl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 85 °C

2: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

3: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C

4: hydrazine hydrate / ethanol / 2 h / 70 °C

5: dichloromethane / 2 h / Molecular sieve

6: sodium tris(acetoxy)borohydride / 2 h / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium carbonate; hydrazine hydrate; trifluoroacetic acid; sodium iodide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 4: |Gabriel Amine Synthesis;
DOI:10.1016/j.ejmech.2013.12.056