methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate

Base Information

• Chemical Name: methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate
• CAS No.: 923672-27-9
• Molecular Formula: C₁₇H₁₆N₃O₇P
• Molecular Weight: 405.304
• Mol file: 923672-27-9.mol

Synonyms:methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate

Chemical Property of methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate

There total 3 articles about methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (5-benzoyl-1-(((di-tert-butoxyphosphoryl)oxy)-methyl)-1H-benzo[d]imidazol-2-yl)carbamate → methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate (923672-27-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h; Schlenk technique; Inert atmosphere;

Reference yield:

mebendazole (31431-39-7) + di-tert-butyl chloromethyl phosphate (229625-50-7) → methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate (923672-27-9) + C17H16N3O7P (923672-28-0)

Guidance literature:

mebendazole; di-tert-butyl chloromethyl phosphate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

With hydrogenchloride; In 1,4-dioxane; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/jm701456r

Reference yield:

mebendazole (31431-39-7) → methyl (5-benzoyl-1-((phosphonooxy)methyl)-1H-benzo[d]imidazol-2-yl)carbamate (923672-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Schlenk technique; Inert atmosphere

1.2: 16 h

2.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Schlenk technique; Inert atmosphere

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

mebendazole

di-tert-butyl chloromethyl phosphate