methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

Base Information

Chemical Name:methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate
CAS No.:1407150-79-1
Molecular Formula:C₂₂H₂₄BrF₂NO₁₁
Molecular Weight:596.333
Hs Code.:

Synonyms:methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

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Chemical Property of methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

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Technology Process of methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

There total 5 articles about methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 1357156-42-3
methyl 1-O-(2-difluoromethyl-4-aminophenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

: 598-21-0
2-Bromoacetyl bromide

: 1407150-79-1
methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

Guidance literature:: With potassium carbonate; In dichloromethane; Cooling with ice;
DOI:10.1021/ic301827p

Reference yield:

: 21085-72-3
1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

: 1407150-79-1
methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

Guidance literature:: Multi-step reaction with 4 steps

1: silver(l) oxide / acetonitrile / 4 h / 0 °C / Darkness

2: diethylamino-sulfur trifluoride / dichloromethane / 8 h / 20 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / acetonitrile / 20 °C / 1368.09 Torr

4: potassium carbonate / dichloromethane / Cooling with ice

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; potassium carbonate; silver(l) oxide; In dichloromethane; acetonitrile;
DOI:10.1021/ic301827p

Reference yield:

: 97-51-8
5-Nitrosalicylaldehyde

: 1407150-79-1
methyl 1-O-(2-difluoromethyl-4-(1-bromoacetamido)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

Guidance literature:: Multi-step reaction with 4 steps

1: silver(l) oxide / acetonitrile / 4 h / 0 °C / Darkness

2: diethylamino-sulfur trifluoride / dichloromethane / 8 h / 20 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / acetonitrile / 20 °C / 1368.09 Torr

4: potassium carbonate / dichloromethane / Cooling with ice

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; potassium carbonate; silver(l) oxide; In dichloromethane; acetonitrile;
DOI:10.1021/ic301827p