(2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester

Base Information

• Chemical Name: (2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester
• CAS No.: 1026563-20-1
• Molecular Formula: C₂₃H₃₄N₄O₂
• Molecular Weight: 398.549
• Mol file: 1026563-20-1.mol

Synonyms:(2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester

Chemical Property of (2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester

There total 8 articles about (2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

11-dodecenyl methanesulfonate (144633-23-8) + (+/-) α-Phenyl tetrazole-5-acetic acid, ethyl ester (149476-31-3) → (2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester (1026563-20-1) + (1-Dodec-11-enyl-1H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester

Guidance literature:

With triethylamine; In acetonitrile; for 16h; Heating;

DOI:10.1021/jm960170f

Reference yield:

10-Undecen-1-ol (112-43-6) → (2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester (1026563-20-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 81 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

2: 98 percent / dimethylsulfoxide / 0.17 h / 80 °C

3: 67 percent / 25percent aq. NaOH / methanol / 24 h / Heating

4: 60 percent / LiAlH₄ / tetrahydrofuran / 16 h / Ambient temperature

5: 99 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

6: 36 percent / Et₃N / acetonitrile / 16 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

DOI:10.1021/jm960170f

Reference yield:

ethyl phenylcyanoacetate (4553-07-5) → (2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid ethyl ester (1026563-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / (n-Bu)3SnN₃ / dioxane / 16 h / Heating

2: Et₃N / acetonitrile / 16 h / Heating

With triethylamine; azido tributyltin (IV); In 1,4-dioxane; acetonitrile;

DOI:10.1021/jm960170f

upstream raw materials:

undec-10-en-1-yl methanesulfonate

(+/-) α-Phenyl tetrazole-5-acetic acid, ethyl ester

11-dodecenyl methanesulfonate

dodec-11-en-1-ol

Downstream raw materials:

(2-Dodec-11-enyl-2H-tetrazol-5-yl)-phenyl-acetic acid