methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate

Base Information

• Chemical Name: methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate
• CAS No.: 1133971-11-5
• Molecular Formula: C₂₃H₁₇NO₄
• Molecular Weight: 371.392
• Mol file: 1133971-11-5.mol

Synonyms:methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate

Chemical Property of methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate

Chemical Property:

Purity/Quality:

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Technology Process of methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate

There total 1 articles about methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

9-oxo-9H-fluorene-1-carboxylic acid (1573-92-8) + methyl 3-amino-2-methylbenzoate (18583-89-6) → methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate (1133971-11-5)

Guidance literature:

9-oxo-9H-fluorene-1-carboxylic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.0833333h;

methyl 3-amino-2-methylbenzoate; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2011.10.091

Reference yield: 94.0%

methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate (1133971-11-5) → 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoic acid (1133971-12-6)

Guidance literature:

methyl 2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoate; With lithium hydroxide monohydrate; In tetrahydrofuran; water; Reflux;

With hydrogenchloride; In dichloromethane; water; pH=2;

DOI:10.1016/j.bmc.2011.10.091

upstream raw materials:

9-oxo-9H-fluorene-1-carboxylic acid

methyl 3-amino-2-methylbenzoate

Downstream raw materials:

2-methyl-3-(9-oxo-9H-fluorene-1-carboxamido)benzoic acid