[(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine

Base Information

• Chemical Name: [(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine
• CAS No.: 848775-01-9
• Molecular Formula: C₁₈H₁₉N₅
• Molecular Weight: 305.382

Synonyms:[(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine

Chemical Property of [(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine

Chemical Property:

Purity/Quality:

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Technology Process of [(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine

There total 5 articles about [(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazine-6-carbonitrile (848774-97-0) → [(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine (848775-01-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; chloroform; for 22h; under 2585.74 Torr;

DOI:10.1021/jm040883v

Reference yield:

benzoic acid hydrazide (613-94-5) → [(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine (848775-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / xylene / 96 h / Heating

2: 66 percent / 1-methyl-pyrrolidin-2-one / 36 h / 200 °C

3: 64 percent / H₂ / Pd/C / CHCl₃; ethanol / 22 h / 2585.74 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol; chloroform; xylene;

DOI:10.1021/jm040883v

Reference yield:

3,6-dichloro-4,5-diazatricyclo[6.2.2.2,7]dodeca-2(7),3,5-triene (202823-67-4) → [(3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazin-6-yl)methyl]amine (848775-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / xylene / 96 h / Heating

2: 66 percent / 1-methyl-pyrrolidin-2-one / 36 h / 200 °C

3: 64 percent / H₂ / Pd/C / CHCl₃; ethanol / 22 h / 2585.74 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol; chloroform; xylene;

DOI:10.1021/jm040883v

upstream raw materials:

3-phenyl-7,8,9,10-tetrahydro-7,10-ethano[1,2,4]triazolo[3,4-a]phthalazine-6-carbonitrile

benzoic acid hydrazide

3,6-dichloro-4,5-diazatricyclo[6.2.2.2,7]dodeca-2⁽⁷⁾,3,5-triene

6-chloro-3-phenyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

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