methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate

Base Information

• Chemical Name: methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate
• CAS No.: 956466-18-5
• Molecular Formula: C₂₈H₄₀F₃NO₂
• Molecular Weight: 479.626
• Mol file: 956466-18-5.mol

Synonyms:methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate

Chemical Property of methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate

There total 8 articles about methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate (884602-78-2) + 3,3-Dimethylbut-1-yne (917-92-0) + 4,4-dimethylpentanal (926-36-3) → methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (956466-18-5)

Guidance literature:

With gold(III) tribromide; In diethyl ether; water; at 70 ℃; for 0.5h; Microwave irradiation;

Reference yield:

methyl {2-[4-(trifluoromethyl)phenyl]-4-pyridinyl}acetate (884600-79-7) → methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (956466-18-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 1034.32 Torr

2.1: water; sodium hydrogencarbonate

3.1: isopropyl alcohol / 20 °C

3.2: 2 h

4.1: water; sodium carbonate

5.1: gold(III) tribromide / diethyl ether; water / 0.5 h / 70 °C / Microwave irradiation

With hydrogenchloride; gold(III) tribromide; water; hydrogen; sodium hydrogencarbonate; sodium carbonate; platinum(IV) oxide; In methanol; diethyl ether; water; isopropyl alcohol;

Reference yield:

3-tert-butyl-acrylic acid ethyl ester (87995-20-8) → methyl {(2S,4R)-1-[(1S)-1-(3,3-dimethylbutyl)-4,4-dimethylpent-2-yn-1-yl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (956466-18-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / platinum(IV) oxide / ethyl acetate / 13 h / 1034.32 - 2068.65 Torr

2: lithium aluminium tetrahydride / diethyl ether / 20 °C

3: pyridinium chlorochromate / dichloromethane / 4 h

4: gold(III) tribromide / diethyl ether; water / 0.5 h / 70 °C / Microwave irradiation

With lithium aluminium tetrahydride; gold(III) tribromide; hydrogen; pyridinium chlorochromate; platinum(IV) oxide; In diethyl ether; dichloromethane; water; ethyl acetate;

upstream raw materials:

(+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

3,3-Dimethylbut-1-yne

4,4-dimethylpentanal

methyl {2-[4-(trifluoromethyl)phenyl]-4-pyridinyl}acetate