[(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

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Chemical Name:[(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester
CAS No.:870196-26-2
Molecular Formula:C₅₈H₇₄N₆O₈SSi₂
Molecular Weight:1071.5
Hs Code.:

[(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

Synonyms:[(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

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Chemical Property of [(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

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Technology Process of [(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

There total 10 articles about [(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 870196-25-1
2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

: 58651-70-0
Z-L-Asn-L-Pro-OH

: 870196-26-2
[(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 1h;
DOI:10.1016/j.bmcl.2005.07.073

Reference yield:

: 870196-19-3
[1-bromomethyl-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

: 870196-26-2
[(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / tetrahydrofuran / 19 h / -78 - 23 °C

2: 82 percent / HCl / ethyl acetate / 0.33 h / 23 °C

3: 61 percent / PyBOP; DIEA / CH₂Cl₂ / 18 h / 23 °C

4: 73 percent / HCl / ethyl acetate / 0.5 h / 23 °C

5: 74 percent / PyBOP; DIEA / CH₂Cl₂ / 1 h / 23 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2005.07.073

Reference yield:

: 870196-18-2
[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-carbamic acid tert-butyl ester

: 870196-26-2
[(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / Et₃N; PPh₃; CBr₄ / CH₂Cl₂ / 18 h / 23 °C

2: 96 percent / tetrahydrofuran / 19 h / -78 - 23 °C

3: 82 percent / HCl / ethyl acetate / 0.33 h / 23 °C

4: 61 percent / PyBOP; DIEA / CH₂Cl₂ / 18 h / 23 °C

5: 73 percent / HCl / ethyl acetate / 0.5 h / 23 °C

6: 74 percent / PyBOP; DIEA / CH₂Cl₂ / 1 h / 23 °C

With hydrogenchloride; carbon tetrabromide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2005.07.073