870196-18-2

Upstream product

• 159846-15-8 N-(tert-Butoxycarbonyl)-O-(tert-butyldiphenylsilyl)-L-threonine methyl ester 
• 148205-40-7 O-tert-butyldiphenylsilyl-L-threonine methyl ester 

Downstream Products

• 870196-26-2 [(S)-2-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propylcarbamoyl}-pyrrolidin-1-yl)-1-carbamoylmethyl-2-oxo-ethyl]-carbamic acid benzyl ester 
• 870196-22-8 [(S)-1-((S)-2-{(S)-1-[(1S,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butyl]-carbamic acid benzyl ester 
• 870196-24-0 {1-[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propyl}-carbamic acid tert-butyl ester 
• 870196-25-1 2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide} 
• 870196-20-6 [2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-carbamic acid tert-butyl ester 
• 870196-21-7 2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylamine 
• 870196-19-3 [1-bromomethyl-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of (2R,3S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases

L-Threonine 2 was converted in seven steps into the protected aminomercaptoalcohol 8, a threonine mimic. This compound 8 was coupled to various oligopeptides to produce two different tetrapeptide analogues, for example, 11 and 17, which were shown to inhibit the Sortase enzymes (SrtA and SrtB) via covalent attachment of the thiol groups of 11 and 17 to the catalytically active cysteine residue of the Sortase enzymes.