6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one

Base Information

Chemical Name:6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one
CAS No.:96720-15-9
Molecular Formula:C₁₅H₁₈Cl₂O₄
Molecular Weight:333.212
Hs Code.:

Synonyms:6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one

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Chemical Property of 6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one

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Technology Process of 6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one

There total 10 articles about 6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 96720-14-8
(3R,5R)-7-(2,4-Dichloro-phenyl)-5-hydroxy-3-methoxymethoxy-heptanoic acid ethyl ester

: 96720-15-9
6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one

Guidance literature:: With toluene-4-sulfonic acid; In benzene;
DOI:10.1016/S0040-4039(00)98429-6

Reference yield:

: p-TsOH_.H₂ O

: 7-(2,4-dichlorophenyl)-5(R)-hydroxy-3(R)-(methoxymethoxy)heptanoate

: 96720-15-9
6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one

Guidance literature:: In benzene;

Reference yield:

: 96720-07-9
(E)-ethyl 4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)but-2-enoate

: 96720-15-9
6(R)-[2-(2,4-dichlorophenyl)ethyl]-4(R)-(methoxymethoxy)tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: HCl / H₂O; tetrahydrofuran / 18 h / Ambient temperature

2: Et₃N, DMAP / CH₂Cl₂ / 18 h / Ambient temperature

3: NaOEt / ethanol / Heating; RT, 2 h, then reflux 4 h

4: 82 percent / dimethylboron bromide / CH₂Cl₂ / 0 deg C 10 min, then RT, 2 h

5: 94 percent / i-Pr₂NEt, DMAP / acetonitrile / 24 h / -3 °C

6: 80 percent / n-Bu₄NF, THF / 3 h / Ambient temperature

7: 1.) CuBr*SMe₂ / 1.) Et₂O, Me₂S, -78 deg C, 15 min, 2.) -78 deg C, 1 h then -23 deg C, 1 h

8: 90 percent / p-TsOH_.H₂O / benzene

With tetrahydrofuran; hydrogenchloride; dmap; copper(I) bromide dimethylsulfide complex; dimethylboron bromide; tetrabutyl ammonium fluoride; sodium ethanolate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)98429-6