1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide

Base Information

• Chemical Name: 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide
• CAS No.: 1220026-26-5
• Molecular Formula: C₂₀H₁₆FN₅O₃S
• Molecular Weight: 425.443

Synonyms:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide

Chemical Property of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide

Chemical Property:

• Boiling Point: 723.7±60.0 °C(Predicted)
• Density: 1.46±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

CCR1antagonist9 99.88% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide

There total 6 articles about 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (1220165-92-3) + (2-(methylsulfonyl)pyridin-4-yl)methanamine hydrochloride (1220166-15-3) → 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide (1220026-26-5)

Guidance literature:

With 4-methyl-morpholine; propylphosphonic anhydride; In 1-methyl-pyrrolidin-2-one; ethyl acetate; at 0 ℃;

Reference yield:

4-fluorophenylhydrazine (371-14-2) → 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide (1220026-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; sodium acetate / water

2: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate; 1-methyl-pyrrolidin-2-one

3: triethylamine; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / ethanol

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium acetate; potassium carbonate; triethylamine; In ethanol; water;

DOI:10.1016/j.bmcl.2018.12.024

Reference yield:

3,5-dibromopyridine-4-carboxaldehyde (70201-42-2) → 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide (1220026-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; sodium acetate / water

2: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate; 1-methyl-pyrrolidin-2-one

3: triethylamine; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / ethanol

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium acetate; potassium carbonate; triethylamine; In ethanol; water;

DOI:10.1016/j.bmcl.2018.12.024

upstream raw materials:

1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

(2-(methylsulfonyl)pyridin-4-yl)methanamine hydrochloride

4-fluorophenylhydrazine

3,5-dibromopyridine-4-carboxaldehyde

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