1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

Base Information

Chemical Name:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid
CAS No.:1220165-92-3
Molecular Formula:C13H8FN3O2
Molecular Weight:257.224
Hs Code.:2933990090
Mol file:1220165-92-3.mol

Synonyms:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

Suppliers and Price of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylicacid 95+%
1g
$ 1170.00

Chemenu
1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylicacid 95%
1g
$ 720.00

Alichem
1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylicacid
1g
$ 793.80

Total 6 raw suppliers

Chemical Property of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

Chemical Property:

PSA：68.01000
LogP:2.25780
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

There total 5 articles about 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220165-87-6
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid ethyl ester

: 1220165-92-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

Guidance literature:: 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid ethyl ester; With water; potassium hydroxide; In methanol; Reflux;

With hydrogenchloride; In methanol; water; pH=5;

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 1220165-92-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

1.2: 20 - 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -20 - -10 °C

2.3: 22 - 55 °C / pH 6 - 7

With isopropylmagnesium chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 1220165-92-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium acetate / water

2: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate; 1-methyl-pyrrolidin-2-one

3: triethylamine; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / ethanol

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium acetate; potassium carbonate; triethylamine; In ethanol; water;
DOI:10.1016/j.bmcl.2018.12.024