[3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride

Base Information

Chemical Name:[3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride
CAS No.:603122-11-8
Molecular Formula:C₂₆H₂₆ClNO₄*ClH
Molecular Weight:488.411
Hs Code.:

Synonyms:[3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride

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Chemical Property of [3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride

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Technology Process of [3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride

There total 13 articles about [3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₄ClNO₆

: 603122-11-8
[3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 603122-32-3
[3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]-tert-butyldimethylsilane

: 603122-11-8
[3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: methanol; sodium hydroxide; water / 20 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; tetrabutyl ammonium fluoride; water; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm800222k

Reference yield:

: C₂₉H₃₂ClNO₄

: 603122-11-8
[3-((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)phenoxy]acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: methanol; sodium hydroxide; water / 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; water; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm800222k