N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

Base Information

Chemical Name:N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide
CAS No.:1428762-82-6
Molecular Formula:C₂₆H₃₈N₆O₅
Molecular Weight:514.625
Hs Code.:

N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

Synonyms:N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

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Chemical Property of N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

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Technology Process of N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

There total 2 articles about N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1428762-78-0
(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

: 1428762-82-6
N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

Guidance literature:: (S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; Inert atmosphere;

With methanol; In dichloromethane; toluene; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2013.01.037

Reference yield:

: 1295471-62-3
C₃₀H₃₅N₅O₇

: 1428762-82-6
N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With diisobutylaluminium hydride; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.01.037

Reference yield:

: 1428762-82-6
N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

: C₂₆H₄₀N₆O₇

Guidance literature:: N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetone; at 20 ℃; for 2h;

With sodium hydrogensulfite; In tetrahydrofuran; water; acetone; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.01.037