(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

Base Information

Chemical Name:(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate
CAS No.:1428762-78-0
Molecular Formula:C₃₄H₄₄N₆O₇
Molecular Weight:648.759
Hs Code.:

(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

Synonyms:(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

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Chemical Property of (S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

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Technology Process of (S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

There total 1 articles about (S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123-75-1
pyrrolidine

: 1295471-62-3
C₃₀H₃₅N₅O₇

: 1428762-78-0
(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

Guidance literature:: at 0 - 20 ℃;
DOI:10.1016/j.bmc.2013.01.037

Reference yield: 85.0%

: 1428762-78-0
(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

: 1428762-82-6
N-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

Guidance literature:: (S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; Inert atmosphere;

With methanol; In dichloromethane; toluene; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2013.01.037

Reference yield:

: 1428762-78-0
(S)-1-((5S,6R,7R,8S,9S)-8-azido-6-hydroxy-2,2,6-trimethyl-9-((3-(prop-1-en-2-yl)phenyl)amino)-7-(pyrrolidine-1-carboxamido)-1,3-dioxaspiro[4.4]nonan-7-yl)ethyl 4-methoxybenzoate

: 1428762-86-0
N-((5S,6R,7R,8S,9S)-9-((3-acetylphenyl)amino)-8-azido-6-hydroxy-7-((S)-1-hydroxyethyl)-2,2,6-trimethyl-1,3-dioxaspiro[4.4]nonan-7-yl)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tetrahydrofuran; acetone; water / 2 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: sodium periodate / tetrahydrofuran; water / 3 h / 20 °C

With sodium periodate; osmium(VIII) oxide; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; acetone; toluene;
DOI:10.1016/j.bmc.2013.01.037