C₃₃H₄₁N₃O₆SSi

Base Information

• Chemical Name: C₃₃H₄₁N₃O₆SSi
• CAS No.: 1374110-24-3
• Molecular Formula: C₃₃H₄₁N₃O₆SSi
• Molecular Weight: 635.857
• Mol file: 1374110-24-3.mol

Synonyms:C₃₃H₄₁N₃O₆SSi

Chemical Property of C₃₃H₄₁N₃O₆SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₁N₃O₆SSi

There total 5 articles about C₃₃H₄₁N₃O₆SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C16H28O5SSi (1374108-64-1) + C17H15N3O2 (1374109-64-4) → C33H41N3O6SSi (1374110-24-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16.33h; Cooling with ice;

Reference yield:

quinoline-2,6-diol (19315-93-6) → C33H41N3O6SSi (1374110-24-3)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

2: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

4: trifluoroacetic acid / chloroform / 0.5 h / 20 °C / Cooling with ice

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16.33 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water;

Reference yield:

6-hydroxy-2-chloroquinoline (577967-89-6) → C33H41N3O6SSi (1374110-24-3)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

3: trifluoroacetic acid / chloroform / 0.5 h / 20 °C / Cooling with ice

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16.33 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water;

upstream raw materials:

quinoline-2,6-diol

C₁₆H₂₈O₅SSi

C₁₇H₁₅N₃O₂

6-hydroxy-2-chloroquinoline

Downstream raw materials:

C₂₇H₂₇N₃O₆S

6-[[2-(tetrahydro-2H-pyran-2-yloxy)-tosyloxy]propoxy]-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)quinoline