5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

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Chemical Name:5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride
CAS No.:1426666-69-4
Molecular Formula:C₂₀H₂₃N₃O₄*ClH
Molecular Weight:405.881
Hs Code.:

Synonyms:5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

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Chemical Property of 5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

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Technology Process of 5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

There total 4 articles about 5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1426669-65-9
2,4-bis(benzyloxy)-6-(4-chlorophenyl)-5-ethylnicotinic acid

: (3aR,6aR)-1-benzyloctahydropyrrolo[3,4-b]pyrrole

: 1426666-69-4
5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

Guidance literature:: With 2-(2^'-di-tert-butylphosphine)biphenylpalladium(II) acetate; sodium t-butanolate; In toluene; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: methyl 2,4-bis(benzyloxy)-6-(4-chlorophenyl)-5-ethylnicotinate

: 1426666-69-4
5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium trimethylsilonate / tetrahydrofuran / 70 °C / Sealed tube

1.2: pH Ca_. 1

2.1: sodium t-butanolate; 2-(2^'-di-tert-butylphosphine)biphenylpalladium(II) acetate / toluene / 16 h / 100 °C / Inert atmosphere

With 2-(2^'-di-tert-butylphosphine)biphenylpalladium(II) acetate; potassium trimethylsilonate; sodium t-butanolate; In tetrahydrofuran; toluene;

Reference yield:

: 1426670-65-6
ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

: 1426666-69-4
5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 0 - 20 °C

2.1: potassium trimethylsilonate / tetrahydrofuran / 70 °C / Sealed tube

2.2: pH Ca_. 1

3.1: sodium t-butanolate; 2-(2^'-di-tert-butylphosphine)biphenylpalladium(II) acetate / toluene / 16 h / 100 °C / Inert atmosphere

With 2-(2^'-di-tert-butylphosphine)biphenylpalladium(II) acetate; di-isopropyl azodicarboxylate; potassium trimethylsilonate; triphenylphosphine; sodium t-butanolate; In tetrahydrofuran; toluene;