ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Base Information

Chemical Name:ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate
CAS No.:1426670-65-6
Molecular Formula:C₁₆H₁₆ClNO₄
Molecular Weight:321.76
Hs Code.:

Synonyms:ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

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Chemical Property of ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

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Technology Process of ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

There total 3 articles about ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 6279-86-3
methanetricarboxylic acid triethyl ester

: 4981-63-9
4-n-butanoylchlorobenzene

: 75-64-9
tert-butylamine

: 1426670-65-6
ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: 4-n-butanoylchlorobenzene; tert-butylamine; With titanium tetrachloride; In dichloromethane; at 0 - 20 ℃;

methanetricarboxylic acid triethyl ester; In diethylene glycol dimethyl ether; at 160 ℃; for 2h;

Reference yield: 53.0%

: 6279-86-3
methanetricarboxylic acid triethyl ester

: C₁₄H₂₀ClN

: 1426670-65-6
ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: In diphenylether; at 160 ℃;
DOI:10.1016/j.bmcl.2016.07.061

Reference yield:

: 4981-63-9
4-n-butanoylchlorobenzene

: 1426670-65-6
ethyl 6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: titanium tetrachloride / dichloromethane / 20 °C

2: diphenylether / 160 °C

With titanium tetrachloride; In diphenylether; dichloromethane;
DOI:10.1016/j.bmcl.2016.07.061