6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Base Information

Chemical Name:6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one
CAS No.:1354745-48-4
Molecular Formula:C₂₃H₁₅ClF₃NO₃
Molecular Weight:445.825
Hs Code.:

Synonyms:6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

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Chemical Property of 6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

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Technology Process of 6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

There total 9 articles about 6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1354745-47-3
6-chloro-4-ethoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinoline

: 1354745-48-4
6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: With hydrogen bromide; acetic acid; In water; at 90 ℃; for 24h;
DOI:10.1021/jm500147k

Reference yield:

: 83842-54-0
HEI 713

: 1354745-48-4
6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

2.2: 8 h / 50 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C / Molecular sieve

4.1: acetic acid; hydrogen bromide / water / 24 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; iodine; potassium carbonate; acetic acid; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm500147k

Reference yield:

: 187386-90-9
C₁₂H₁₄ClNO₂

: 1354745-48-4
6-chloro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dowtherm A / 0.33 h / 250 °C

2.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

3.2: 8 h / 50 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C / Molecular sieve

5.1: acetic acid; hydrogen bromide / water / 24 h / 90 °C

With dowtherm A; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; iodine; potassium carbonate; acetic acid; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm500147k