N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE

Base Information

Chemical Name:N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE
CAS No.:958332-01-9
Molecular Formula:C₁₇H₂₃N₃O₂S
Molecular Weight:333.455
Hs Code.:

Synonyms:N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE

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Chemical Property of N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE

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Technology Process of N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE

There total 4 articles about N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[4-methyl-6-(1-{(1R)-[1-phenylethyl]imino}ethyl)pyridin-3-yl]methanesulfonamide

: 958332-01-9
N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE

Guidance literature:: N-[4-methyl-6-(1-{(1R)-[1-phenylethyl]imino}ethyl)pyridin-3-yl]methanesulfonamide; With methanol; sodium tetrahydroborate; In tetrahydrofuran; at -8 - 20 ℃; for 10.5h; Inert atmosphere;

With ethanol; water; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 66909-38-4
5-amino-2-chloro-4-methylpyridine

: 958332-01-9
N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 2 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

3.1: tetrahydrofuran / 2 h / 0 - 20 °C

3.2: Brine

4.1: titanium tetrachloride / tetrahydrofuran / 4 h / 20 °C

5.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 10.5 h / -8 - 20 °C / Inert atmosphere

5.2: 1 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; titanium tetrachloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 958331-93-6
N-(6-CHLORO-4-METHYLPYRIDIN-3-YL)METHANESULFONAMIDE

: 958332-01-9
N-[4-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]METHANESULFONAMIDE

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

2.1: tetrahydrofuran / 2 h / 0 - 20 °C

2.2: Brine

3.1: titanium tetrachloride / tetrahydrofuran / 4 h / 20 °C

4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 10.5 h / -8 - 20 °C / Inert atmosphere

4.2: 1 h / 20 °C

With methanol; sodium tetrahydroborate; titanium tetrachloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;