66909-38-4

Basic information

• Product Name: 3-AMINO-6-CHLORO-4-PICOLINE
• Synonyms: 5-AMINO-2-CHLORO-4-PICOLINE;3-AMINO-6-CHLORO-4-PICOLINE;2-CHLORO-5-AMINO-4-PICOLINE;3-AMINO-6-CHLORO-4-METHYLPYRIDINE;3-Amino-6-chloro-4-picoline ,98%;2-CHLORO-4-METHYL-5-AMINOPYRIDINE;6-chloro-4-methylpyridin-3-amine;6-chloro-4-Methyl-3-PyridinaMine
• CAS NO: 66909-38-4
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.58618
• Product Categories: Pyridine;Amino-pyridine series
• Mol File: 66909-38-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 69-73 °C
• Boiling Point: 310℃
• Flash Point: 141℃
• Appearance: Pale orange/Solid
• Density: 1.260
• Vapor Pressure: 0.000627mmHg at 25°C
• Refractive Index: 1.4877 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.79±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-AMINO-6-CHLORO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-6-CHLORO-4-PICOLINE(66909-38-4)
• EPA Substance Registry System: 3-AMINO-6-CHLORO-4-PICOLINE(66909-38-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-41-22-37/38
• Safety Statements: 36/37/39-26-39
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 66909-38-4(Hazardous Substances Data)

Usage

Chemical Properties

bordeaux to brownish powder

Uses

5-Amino-2-chloro-4-methylpyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

InChI:InChI=1/C6H7ClN2/c1-4-2-6(7)9-3-5(4)8/h2-3H,8H2,1H3

Upstream product

• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 

Downstream Products

• 1073182-76-9 3-amino-6-chloro-4-methyl-pyridine-2-carboxylic acid 
• 6635-92-3 5-acetamido-2-chloro-4-methylpyridine 
• 76006-04-7 1-acetyl-5-chloro-1H-pyrazolo<3,4-c>pyridine 

Relevant articles and documents

MICROBIOCIDAL DERIVATIVES

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, and especially fungicides.

Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines

A series of new pyrazolo[3,4-c]pyridines bearing various 1, 3, 5 or 1, 3, 7 pattern substitutions, were designed and synthesized. Some of them showed interesting inhibitory activity mainly against glycogen synthase kinase 3 (GSK3)α/β as well as against cdc2-like kinases 1 (CLK1) and dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), with good selectivity and remarkable structure-activity relationships (SARs), without being cytotoxic. Molecular simulations in correlation with biological data revealed the importance of the existence of N1-H as well as the absence of a bulky 7-substituent.

ERK INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a method of inhibiting ERK2 in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of Formula (I). The invention also provides a method for treating cancer in a patient in need of such treatment, said method comprising administering to said patient an effective amount of at least one compound of Formula (I).