(1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

Base Information

Chemical Name:(1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate
CAS No.:1334542-44-7
Molecular Formula:C₃₃H₄₂N₄O₆
Molecular Weight:590.72
Hs Code.:

Synonyms:(1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

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Chemical Property of (1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

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Technology Process of (1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

There total 6 articles about (1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334542-35-6
(1R)-1-phenylethyl (1-pyridin-2-yl-1H-imidazol-4-yl)acetate

: 1334542-43-6
di-tert-butyl [(3R)-3-methyl-4-oxobutyl]imidodicarbonate

: 1334542-44-7
(1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

: 1334542-45-8
(1R)-1-phenylethyl (2E,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

Guidance literature:: (1R)-1-phenylethyl (1-pyridin-2-yl-1H-imidazol-4-yl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.16667h; Inert atmosphere;

di-tert-butyl [(3R)-3-methyl-4-oxobutyl]imidodicarbonate; In tetrahydrofuran; at -78 - -20 ℃; for 7.16667h;

Reference yield:

: 147915-53-5
(S)-methyl-3-hydroxy-2-methylpropanoate

: 1334542-44-7
(1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

: 1334542-45-8
(1R)-1-phenylethyl (2E,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 24 h / 20 °C / Cooling with ice

2.1: diisobutylaluminium hydride / tetrahydrofuran / 2.08 h / -78 °C / Inert atmosphere

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 15.5 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

5.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.92 h / -78 °C / Inert atmosphere

5.2: 2.08 h / -78 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

6.2: 7.17 h / -78 - -20 °C

With 1H-imidazole; oxalyl dichloride; tributylphosphine; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dimethyl sulfoxide; lithium hexamethyldisilazane; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 888483-86-1
methyl (3R)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-methylbutyrate

: 1334542-44-7
(1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

: 1334542-45-8
(1R)-1-phenylethyl (2E,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 2.08 h / -78 °C / Inert atmosphere

2.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 15.5 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.92 h / -78 °C / Inert atmosphere

4.2: 2.08 h / -78 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

5.2: 7.17 h / -78 - -20 °C

With oxalyl dichloride; tributylphosphine; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dimethyl sulfoxide; lithium hexamethyldisilazane; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; toluene;