(1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate

Base Information

Chemical Name:(1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate
CAS No.:1334542-46-9
Molecular Formula:C₃₄H₄₄N₄O₆
Molecular Weight:604.747
Hs Code.:

Synonyms:(1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate

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Chemical Property of (1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate

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Technology Process of (1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate

There total 7 articles about (1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334542-44-7
(1R)-1-phenylethyl (2Z,4R)-6-[bis(tert-butoxycarbonyl)amino]-4-methyl-2-[1-(pyridin-2-yl)-1H-imidazol-4-yl]hex-2-enoate

: 1334542-46-9
(1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate

Guidance literature:: With trimethylsulfoxonium iodide; sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃;

Reference yield:

: 1334542-42-5
di-tert-butyl [(3R)-4-hydroxy-3-methylbutyl]imidodicarbonate

: 1334542-46-9
(1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.92 h / -78 °C / Inert atmosphere

1.2: 2.08 h / -78 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

2.2: 7.17 h / -78 - -20 °C

3.1: trimethylsulfoxonium iodide; sodium hydride / mineral oil; dimethyl sulfoxide / 20 °C

With oxalyl dichloride; trimethylsulfoxonium iodide; sodium hydride; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; mineral oil;

Reference yield:

: 1334542-43-6
di-tert-butyl [(3R)-3-methyl-4-oxobutyl]imidodicarbonate

: 1334542-46-9
(1R)-1-phenylethyl 2-{(2R)-4-[bis(tert-butoxycarbonyl)amino]butan-2-yl}-1-[1-(pyridin-2-yl)-1H-imidazol-4-yl]cyclopropane carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

1.2: 7.17 h / -78 - -20 °C

2.1: trimethylsulfoxonium iodide; sodium hydride / mineral oil; dimethyl sulfoxide / 20 °C

With trimethylsulfoxonium iodide; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;