(R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester

Base Information

Chemical Name:(R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester
CAS No.:346578-02-7
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:

Synonyms:(R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester

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Chemical Property of (R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester

Chemical Property:

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Technology Process of (R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester

There total 6 articles about (R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183140-29-6
N-isobutyloxycarbonyl-(S)-alanine

: 346578-02-7
(R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 5 h / 20 °C

2: 92 percent / SnCl₄ / CH₂Cl₂ / 20 h / 25 °C

3: LiHMDS / tetrahydrofuran / 3.5 h / -25 - 20 °C

4: methanol / 20 °C

With oxalyl dichloride; tin(IV) chloride; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.2533/chimia.2006.566

Reference yield:

: 346577-99-9
(2S,4S)-2-(biphenyl-4-yl)-4-methyl-5-oxo-oxazolidine-3-carboxylic acid isobutyl ester

: 346578-02-7
(R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiHMDS / tetrahydrofuran / 3.5 h / -25 - 20 °C

2: methanol / 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.2533/chimia.2006.566

Reference yield:

: 100-39-0
benzyl bromide

: 346578-02-7
(R)-2-isobutoxycarbonylamino-2-methyl-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / LiN(SiMe₃)2 / tetrahydrofuran; hexane / -27 °C

2: 97 percent / methanol

With lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/S0040-4039(01)00403-8