4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
CAS No.:1147014-69-4
Molecular Formula:C₂₉H₃₁N₅
Molecular Weight:449.599
Hs Code.:

Synonyms:4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

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Chemical Property of 4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

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Technology Process of 4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 7 articles about 4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₃₇N₅O₂S

: 1147014-69-4
4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; for 0.5h; Heating / reflux;

Reference yield:

: 934524-10-4
2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine

: 1147014-69-4
4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.08 h

1.2: 1 h / 80 °C

2.1: triethylamine / palladium diacetate; tri-tert-butyl phosphine / N,N-dimethyl-formamide; toluene / 0.33 h / 180 °C / Microwave irradiation

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide; toluene / 0.5 h / Heating / reflux

With tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; tri-tert-butyl phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1147014-57-0
[(2-isopropylphenyl)ethynyl]trimethylsilane

: 1147014-69-4
4-((2-isopropylphenyl)ethynyl)-N-(4-(piperidin-1-ylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; potassium hydroxide / 1 h / 20 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.08 h

2.2: 1 h / 80 °C

3.1: triethylamine / palladium diacetate; tri-tert-butyl phosphine / N,N-dimethyl-formamide; toluene / 0.33 h / 180 °C / Microwave irradiation

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide; toluene / 0.5 h / Heating / reflux

With methanol; potassium hydroxide; tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; tri-tert-butyl phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;