1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one

Base Information

• Chemical Name: 1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one
• CAS No.: 1447968-42-4
• Molecular Formula: C₁₇H₁₈N₄O₄
• Molecular Weight: 342.354

Synonyms:1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one

Chemical Property of 1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one

Chemical Property:

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Technology Process of 1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one

There total 5 articles about 1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-(4-acetylphenyl)-5-oxoprolyl chloride (1447968-48-0) + zinc dimethyl imidodicarbonimidate → 1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one (1447968-42-4)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere; Molecular sieve;

DOI:10.1055/s-0033-1338298

Reference yield:

4-Iodoacetophenone (13329-40-3) → 1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one (1447968-42-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 50 °C / Inert atmosphere

2.1: sodium hydroxide / water / 1 h / 80 °C

2.2: 20 °C / pH 5 - 6

3.1: thionyl chloride / dichloromethane / Inert atmosphere; Reflux

4.1: pyridine / dichloromethane / 24 h / 20 °C / Inert atmosphere; Molecular sieve

With pyridine; copper(l) iodide; thionyl chloride; caesium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1055/s-0033-1338298

Reference yield:

methyl 5-oxopyrrolidine-2-carboxylate (4931-66-2,54571-66-3,64700-65-8) → 1-(4-acetylphenyl)-5-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-2-one (1447968-42-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 50 °C / Inert atmosphere

2.1: sodium hydroxide / water / 1 h / 80 °C

2.2: 20 °C / pH 5 - 6

3.1: thionyl chloride / dichloromethane / Inert atmosphere; Reflux

4.1: pyridine / dichloromethane / 24 h / 20 °C / Inert atmosphere; Molecular sieve

With pyridine; copper(l) iodide; thionyl chloride; caesium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1055/s-0033-1338298

upstream raw materials:

methyl 5-oxopyrrolidine-2-carboxylate

4-Iodoacetophenone

methyl N-(4-acetylphenyl)pyroglutamate

1-(4-acetylphenyl)-5-oxoprolyl chloride

Downstream raw materials:

6-[1-(4-acetylphenyl)-5-oxopyrrolidin-2-yl]-1,3,5-triazine-2,4(1H,3H)-dione

4-[1-(4-acetylphenyl)-5-oxopyrrolidin-2-yl]-6-methoxy-1,3,5-triazin-2(1H)-one

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