Technology Process of 2-methoxy-1-naphthyl (2-acetamido-4,6-dimethoxy)phenyl ketone
There total 2 articles about 2-methoxy-1-naphthyl (2-acetamido-4,6-dimethoxy)phenyl ketone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
aluminium trichloride;
In
dichloromethane;
at 0 - 20 ℃;
for 15h;
DOI:10.1021/jm0602007
- Guidance literature:
-
Multi-step reaction with 2 steps
1: thionyl chloride / 3 h / 60 °C
2: 25.1 g / AlCl3 / CH2Cl2 / 15 h / 0 - 20 °C
With
aluminium trichloride; thionyl chloride;
In
dichloromethane;
2: Friedel-Crafts reaction;
DOI:10.1021/jm0602007
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 95 percent / NaH / dimethylformamide / 15.5 h / 0 - 20 °C
2.1: 94 percent / aq. HBr; AcOH / 96 h / Heating
3.1: K2CO3 / dimethylformamide / 0.25 h / 65 °C
3.2: 40 percent / KI / dimethylformamide / 24 h / 65 °C
4.1: 95 percent / dimethylformamide / 3 h / 130 °C
5.1: NaH / dimethylformamide / 0.5 h / 0 °C
5.2: 65 percent / dimethylformamide / 4 h / 20 °C
6.1: 71 percent / osmium tetroxide; N-methylmorpholine N-oxide dihydrate / 2-methyl-propan-2-ol; tetrahydrofuran; H2O / 96 h / 20 °C
7.1: 38 percent / pyridine; 4-(dimethylamino)pyridine / 48 h / 20 °C
With
pyridine; dmap; osmium(VIII) oxide; hydrogen bromide; sodium hydride; potassium carbonate; acetic acid; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
4.1: Claisen rearrangement;
DOI:10.1021/jm0602007
