benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

Base Information

Chemical Name:benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate
CAS No.:139607-38-8
Molecular Formula:C₃₆H₃₂N₄O₇S₂
Molecular Weight:696.805
Hs Code.:

Synonyms:benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

Suppliers and Price of benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

There total 6 articles about benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 139607-37-7
benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate 1β-sulfoxide

: 139607-38-8
benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

Guidance literature:: With acetyl chloride; tin(ll) chloride; In N,N-dimethyl-formamide; a) 0 deg C, 15 min, b) to room temperature, 45 min;
DOI:10.1021/jo00034a027

Reference yield:

: 30200-18-1
7-β-<2-(thien-2-yl)acetamido>-3-hydroxymethyl-2-cephem-4-carboxylic acid

: 139607-38-8
benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / acetone; acetonitrile / 1 h / Ambient temperature

2: 74 percent / 2,6-lutidine / DMAP / tetrahydrofuran / 0 deg C to room temperature, overnight

3: 86 percent / m-CPBA / CH₂Cl₂ / 1 h / 0 °C

4: 65 percent / pyridine / i-Pr₂NEt / 16 h / Ambient temperature

5: 76 percent / stannous chloride, acetyl chloride / dimethylformamide / a) 0 deg C, 15 min, b) to room temperature, 45 min

With pyridine; 2,6-dimethylpyridine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; tin(ll) chloride; dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo00034a027

Reference yield:

: 57832-67-4
benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate

: 139607-38-8
benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / 2,6-lutidine / DMAP / tetrahydrofuran / 0 deg C to room temperature, overnight

2: 86 percent / m-CPBA / CH₂Cl₂ / 1 h / 0 °C

3: 65 percent / pyridine / i-Pr₂NEt / 16 h / Ambient temperature

4: 76 percent / stannous chloride, acetyl chloride / dimethylformamide / a) 0 deg C, 15 min, b) to room temperature, 45 min

With pyridine; 2,6-dimethylpyridine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; tin(ll) chloride; dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00034a027