benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate

Base Information

• Chemical Name: benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate
• CAS No.: 57832-67-4
• Molecular Formula: C₂₇H₂₄N₂O₅S₂
• Molecular Weight: 520.63

Synonyms:benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate

Chemical Property of benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate

Chemical Property:

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Technology Process of benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate

There total 3 articles about benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

7-β-<2-(thien-2-yl)acetamido>-3-hydroxymethyl-2-cephem-4-carboxylic acid (30200-18-1) + diazodiphenylmethane (908093-98-1) → benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-(hydroxymethyl)-2-cephem-4-carboxylate (57832-67-4)

Guidance literature:

In acetone; acetonitrile; for 1h; Ambient temperature;

DOI:10.1021/jo00034a027

Reference yield:

7-(2-thienylacetamido)-3-hydroxymethyl-3-cephem-4-carboxylic acid lactone + benzhydryl 7-(2-thienylacetamido)-3-(3-hydroxybutanoyloxymethyl)-2-cephem-4-carboxylate + sodium hydrogencarbonate (144-55-8) → benzhydryl 3-hydroxymethyl-7β-(thiophen-2-yl-acetamido)-ceph-2-em-4-carboxylate (57832-67-4,58462-81-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

Reference yield:

→ benzhydryl 3-hydroxymethyl-7β-(thiophen-2-yl-acetamido)-ceph-2-em-4-carboxylate (57832-67-4,58462-81-0)

Guidance literature:

upstream raw materials:

sodium hydrogencarbonate

7-β-<2-(thien-2-yl)acetamido>-3-hydroxymethyl-2-cephem-4-carboxylic acid

diazodiphenylmethane

Downstream raw materials:

benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<(4-nitrophenoxy)carbonyl>oxy>methyl>-2-cephem-4-carboxylate

7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylic acid

7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylic acid 1β-sulfoxide

benzhydryl 7β-(2-(thien-2-yl)acetamido)-3-<<<<(4-methylbenzoyl)hydrazino>carbonyl>oxy>methyl>-3-cephem-4-carboxylate 1β-sulfoxide

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