7-amino-2H-1,4-benzoxazin-3(4H)-one

Base Information

Chemical Name:7-amino-2H-1,4-benzoxazin-3(4H)-one
CAS No.:26215-14-5
Molecular Formula:C8H8N2O2
Molecular Weight:164.164
Hs Code.:2934999090
European Community (EC) Number:681-750-1
DSSTox Substance ID:DTXSID20949088
Wikidata:Q82926928
Mol file:26215-14-5.mol

Synonyms:26215-14-5;7-amino-2H-1,4-benzoxazin-3(4H)-one;7-Amino-4H-benzo[1,4]oxazin-3-one;7-Amino-2H-1,4-benzoxazin-3[4H]one;7-AMINO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;7-amino-4H-1,4-benzoxazin-3-one;MFCD03425794;7-AMINO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-3-ONE;7-amino-2H-1,4-benzoxazin-3-ol;7-Amino-2H-1,4-benzoxazin-3(4H)one;2H-1,4-Benzoxazin-3(4H)-one,7-amino-;CINNAMYLMETHACRYLATE;Oprea1_235706;SCHEMBL276741;DTXSID20949088;RUZXDTHZHJTTRO-UHFFFAOYSA-N;BBL011145;STK652836;STK802457;7-Amino-2H-1,4-benzoxazine-3-one;7-azanyl-4H-1,4-benzoxazin-3-one;AKOS000717812;AKOS005583640;MB02829;7-amino-4H-benzo[1,4]oxazine-3-one;SY060762;BB 0237044;CS-0085211;EN300-29638;6T-0236;A818324;2H-1,4-BENZOXAZIN-3(4H)-ONE, 7-AMINO-;7-amino-3-oxo-3,4-dihydro-(2H)-1,4-benzoxazine;7-Amino-2H-1,4-benzoxazin-3(4H)-one, AldrichCPR;Z285498242

Suppliers and Price of 7-amino-2H-1,4-benzoxazin-3(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Amino-2H-1,4-benzoxazin-3(4H)-one
500mg
$ 130.00

SynQuest Laboratories
7-Amino-2H-1,4-benzoxazin-3(4H)-one
1 g
$ 144.00

Matrix Scientific
7-Amino-2H-1,4-benzoxazin-3(4H)-one
1g
$ 54.00

Matrix Scientific
7-Amino-2H-1,4-benzoxazin-3(4H)-one
500mg
$ 34.00

J&W Pharmlab
7-Amino-4H-benzo[1,4]oxazin-3-one 96%
25g
$ 788.00

Heterocyclics
7-Amino-2H-benzo[b][1,4]oxazin-3(4H)-one 97%
25g
$ 517.00

Heterocyclics
7-Amino-2H-benzo[b][1,4]oxazin-3(4H)-one 97%
5g
$ 167.00

Crysdot
7-Amino-2H-1,4-benzoxazin-3[4H]one 97%
1g
$ 105.00

Crysdot
7-Amino-2H-1,4-benzoxazin-3[4H]one 97%
5g
$ 320.00

Crysdot
7-Amino-2H-1,4-benzoxazin-3[4H]one 97%
10g
$ 530.00

Total 26 raw suppliers

Chemical Property of 7-amino-2H-1,4-benzoxazin-3(4H)-one

Chemical Property:

Vapor Pressure:9.23E-08mmHg at 25°C
Melting Point:215-218°C
Refractive Index:1.624
Boiling Point:434.8 °C at 760 mmHg
PKA:12.43±0.20(Predicted)
Flash Point:216.7 °C
PSA：64.35000
Density:1.344 g/cm³
LogP:1.31890
Storage Temp.:2-8°C(protect from light)
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:164.058577502
Heavy Atom Count:12
Complexity:196

Purity/Quality:

99%, ^*data from raw suppliers

7-Amino-2H-1,4-benzoxazin-3(4H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,Xn
Statements: 22-52

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC2=C(O1)C=C(C=C2)N
Uses 7-Amino-2H-1,4-benzoxazin-3(4H)-one Is a useful reagent used in the preparation of benzo-oxazinones that functions as anticonvulsants.

Technology Process of 7-amino-2H-1,4-benzoxazin-3(4H)-one

There total 6 articles about 7-amino-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 81721-86-0
7-nitro-4H-benzo[1,4]oxazin-3-one

: 26215-14-5
7-amino-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 121-88-0
5-Nitro-2-aminophenol

: 26215-14-5
7-amino-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Et₃BnNCl; NaHCO₃ / CHCl₃ / 17 h / 0 - 50 °C

2: 79 percent / H₂ / Pd/C / methanol / 2 h / 20 °C / 760 Torr

With N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; chloroform;
DOI:10.1021/jm049485i

Reference yield:

: 95-55-6
2-amino-phenol

: 26215-14-5
7-amino-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / tetrachloromethane / 16.33 h / 0 - 60 °C

2: acetic acid; nitric acid / 0.25 h / 20 °C / Cooling with ice

3: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 20 °C

With palladium 10% on activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; nitric acid; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; tetrachloromethane;