4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1025988-45-7
Molecular Formula:C₂₇H₄₄N₂O₇S
Molecular Weight:540.722
Hs Code.:

Synonyms:4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 10 articles about 4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 1025988-45-7
4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 73 percent / NaOH / dioxane / 18 h

2: 78 percent / imidazol, I₂, triphenylphosphine chloride / toluene / 1.5 h

3: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature

4: 100 percent / NaOH / methanol / 16 h

5: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) EtOAc, -15 deg C, 0.5 h, 2.) EtOAc, Et₂O, 0 deg C, 20 min

6: 24 percent / silver benzoate, Et₃N / 0.5 h / Ambient temperature

7: H₂ / 10percent Pd/C / ethanol / 12 h

8: NaHCO₃ / ethyl acetate / 18 h / Ambient temperature

9: LiOH / tetrahydrofuran; methanol; H₂O / 18 h

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; sodium hydroxide; hydrogen; iodine; silver benzoate; sodium hydrogencarbonate; caesium carbonate; triethylamine; dichlorotriphenylphosphorane; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 1025988-45-7
4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / H₂ / 10percent Pd/C / acetic acid / 48 h / 2585.7 Torr

2: 73 percent / NaOH / dioxane / 18 h

3: 78 percent / imidazol, I₂, triphenylphosphine chloride / toluene / 1.5 h

4: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature

5: 100 percent / NaOH / methanol / 16 h

6: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) EtOAc, -15 deg C, 0.5 h, 2.) EtOAc, Et₂O, 0 deg C, 20 min

7: 24 percent / silver benzoate, Et₃N / 0.5 h / Ambient temperature

8: H₂ / 10percent Pd/C / ethanol / 12 h

9: NaHCO₃ / ethyl acetate / 18 h / Ambient temperature

10: LiOH / tetrahydrofuran; methanol; H₂O / 18 h

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; sodium hydroxide; hydrogen; iodine; silver benzoate; sodium hydrogencarbonate; caesium carbonate; triethylamine; dichlorotriphenylphosphorane; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007

Reference yield:

: 156185-63-6
N-Boc-piperidin-4-yl-propanol

: 1025988-45-7
4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / imidazol, I₂, triphenylphosphine chloride / toluene / 1.5 h

2: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature

3: 100 percent / NaOH / methanol / 16 h

4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) EtOAc, -15 deg C, 0.5 h, 2.) EtOAc, Et₂O, 0 deg C, 20 min

5: 24 percent / silver benzoate, Et₃N / 0.5 h / Ambient temperature

6: H₂ / 10percent Pd/C / ethanol / 12 h

7: NaHCO₃ / ethyl acetate / 18 h / Ambient temperature

8: LiOH / tetrahydrofuran; methanol; H₂O / 18 h

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; sodium hydroxide; hydrogen; iodine; silver benzoate; sodium hydrogencarbonate; caesium carbonate; triethylamine; dichlorotriphenylphosphorane; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007