tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate
CAS No.:629655-39-6
Molecular Formula:C₂₇H₃₂ClN₇O₃
Molecular Weight:538.049
Hs Code.:

Synonyms:tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate

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Technology Process of tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate

There total 13 articles about tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 629655-38-5
tert-butyl 2-(2-{[3-({[5-chloro-2-(1H-1,2,4-triazol-1-yl)phenyl]acetyl}amino)-4-hydroxypyridin-2-yl]amino}ethyl)piperidine-1-carboxylate

: 629655-39-6
tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane;
DOI:10.1016/j.bmcl.2005.07.022

Reference yield:

: 629655-36-3
tert-butyl 2-{2-[(4-hydroxy-3-nitropyridin-2-yl)amino]ethyl}piperidine-1-carboxylate

: 629655-39-6
tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethyl acetate / 2327.17 Torr

2: EDC; HOAt; (iPr)2NEt / dimethylformamide

3: iPrO₂CN=NCO-iPr; Ph₃P / CH₂Cl₂

With 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.07.022

Reference yield:

: 89282-12-2
2,4-dihydroxy-3-nitropyridine

: 629655-39-6
tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: POCl₃; Bn(Et)3NCl / acetonitrile / Heating

2: CsOAc / dimethylformamide / 80 °C

3: (iPr)2NEt / ethanol / Heating

4: H₂ / Pd/C / ethyl acetate / 2327.17 Torr

5: EDC; HOAt; (iPr)2NEt / dimethylformamide

6: iPrO₂CN=NCO-iPr; Ph₃P / CH₂Cl₂

With 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; cesium acetate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 6: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.07.022