629655-38-5

Upstream product

• 629655-21-6 2-(1,2,4-triazol-1-yl)-5-chlorophenylacetic acid 
• 629655-37-4 tert-butyl 2-{2-[(3-amino-4-hydroxypyridin-2-yl)amino]ethyl}piperidine-1-carboxylate 
• 629655-23-8 2-chloro-3-nitro-4-hydroxypyridine 
• 449758-31-0 5-Chloro-2-(1H-1,2,4-triazol-1-yl)benzonitrile 
• 21663-61-6 2,5-dichlorobenzonitrile 
• 5975-12-2 2,4-dichloro-3-nitro-pyridine 
• 89282-12-2 2,4-dihydroxy-3-nitropyridine 
• 629655-36-3 tert-butyl 2-{2-[(4-hydroxy-3-nitropyridin-2-yl)amino]ethyl}piperidine-1-carboxylate 
• 629655-19-2 5-chloro-2-(1H-1,2,4-triazol-1-yl)benzoic acid 
• 629655-20-5 [5-chloro-2-(1H-1,2,4-triazol-1-yl)phenyl]acetonitrile 
• 404922-80-1 1-[2-(bromomethyl)-4-chlorophenyl]-1H-1,2,4-triazole 
• 404922-74-3 [5-chloro-2-(1H-1,2,4-triazol-1-yl)phenyl]methanol 

Downstream Products

• 629655-39-6 tert-butyl 2-[2-({2-[5-chloro-2-(1H-1,2,4-triazol-1-yl)benzyl][1,3]oxazolo[4,5-c]pyridin-4-yl}amino)ethyl]piperidine-1-carboxylate 

Relevant academic research and scientific papers

Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization

Thrombin-inhibitor X-ray crystal structures, in combination with the installation of binding elements optimized within the pyrazinone series of thrombin inhibitors, were utilized to transform a weak triazolopyrimidine lead into a series of potent oxazolop

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof.