N-(2-Methylphenethyl)phthalimide

Base Information

• Chemical Name: N-(2-Methylphenethyl)phthalimide
• CAS No.: 117661-73-1
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.312
• DSSTox Substance ID: DTXSID701209389
• Nikkaji Number: J672.494I
• Mol file: 117661-73-1.mol

Synonyms:N-(2-Methylphenethyl)phthalimide;DTXSID701209389;117661-73-1;2-[2-(2-Methylphenyl)ethyl]-1H-isoindole-1,3(2H)-dione

Chemical Property of N-(2-Methylphenethyl)phthalimide

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 265.110278721
• Heavy Atom Count: 20
• Complexity: 369

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=CC=C1CCN2C(=O)C3=CC=CC=C3C2=O

Technology Process of N-(2-Methylphenethyl)phthalimide

There total 3 articles about N-(2-Methylphenethyl)phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

phthalic anhydride (85-44-9) + 2-methylphenethylamine (55755-16-3) → 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione (117661-73-1)

Guidance literature:

at 150 ℃;

DOI:10.3987/R-1987-10-2683

Reference yield:

1-chloromethyl-2-methylbenzene (552-45-4) → 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione (117661-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / benzyltriethylammonium chloride / benzene; H₂O

2: 94 percent / NaBH₄, CF₃COOH

3: 72 percent / 150 °C

With sodium tetrahydroborate; N-benzyl-N,N,N-triethylammonium chloride; trifluoroacetic acid; In water; benzene;

DOI:10.3987/R-1987-10-2683

Reference yield:

2-tolylmethylnitrile (22364-68-7) → 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione (117661-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NaBH₄, CF₃COOH

2: 72 percent / 150 °C

With sodium tetrahydroborate; trifluoroacetic acid;

DOI:10.3987/R-1987-10-2683

upstream raw materials:

phthalic anhydride

2-methylphenethylamine

1-chloromethyl-2-methylbenzene

2-tolylmethylnitrile